ea0070oc3.6 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020
Othonos Nantia
, Pofi Riccardo
, Arvaniti Anastasia
, Whittaker Andrew
, Stewart Paul
, Coleman Ruth
, Agbaje Olorunsola
, Milton Joanne
, Holman Rury
, Tomlinson Jeremy W
Glucocorticoids (GC) are commonly prescribed, but their use is associated with significant adverse metabolic and bone effects. 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) regenerates active GC within tissues, tightly controlling the availability of GC to bind and activate the GC receptor; Our preclinical data have shown that 11β-HSD1 knock out mice resist the adverse effects of exogenous GC excess. We have now conducted a randomized, double-blind, placebo...